Functional balance between haemagglutinin and neuraminidase in influenza virus infections
Identifieur interne : 001775 ( Main/Exploration ); précédent : 001774; suivant : 001776Functional balance between haemagglutinin and neuraminidase in influenza virus infections
Auteurs : Ralf Wagner [Allemagne] ; Mikhail Matrosovich [Allemagne, Russie] ; Hans-Dieter Klenk [Allemagne]Source :
- Reviews in Medical Virology [ 1052-9276 ] ; 2002-05.
English descriptors
- Teeft :
- Amino, Arch virol, Avian, Cell culture, Cellular receptors, Copyright, Embryonated chicken eggs, Functional balance, Glycoprotein, Haemagglutinin, Hemagglutinin, Host cells, Human viruses, Inhibitor, John wiley sons, Mdck cells, Membrane fusion, Molecular species, Mutant, Mutation, Neuraminidase, Neuraminidase activity, Neuraminidase inhibitors, Parent virus, Progeny, Progeny virions, Reassortants, Receptor, Receptor binding, Receptor binding site, Recombinant viruses, Replication, Sialic, Sialic acid, Sialic acid receptors, Sialic acids, Surface glycoproteins, Viral, Virol, Virology, Virus, Virus neuraminidase, Virus reassortants, Virus release, Virus replication.
Abstract
Influenza A and B viruses carry two surface glycoproteins, the haemagglutinin (HA) and the neuraminidase (NA). Both proteins have been found to recognise the same host cell molecule, sialic acid. HA binds to sialic acid‐containing receptors on target cells to initiate virus infection, whereas NA cleaves sialic acids from cellular receptors and extracellular inhibitors to facilitate progeny virus release and to promote the spread of the infection to neighbouring cells. Numerous studies performed recently have revealed that an optimal interplay between these receptor‐binding and receptor‐destroying activities of the surface glycoproteins is required for efficient virus replication. An existing balance between the antagonistic HA and NA functions of individual viruses can be disturbed by various events, such as reassortment, virus transmission to a new host, or therapeutic inhibition of neuraminidase. The resulting decrease in the viral replicative fitness is usually overcome by restoration of the functional balance due to compensatory mutations in HA, NA or both proteins. Copyright © 2002 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/rmv.352
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000482
- to stream Istex, to step Curation: 000482
- to stream Istex, to step Checkpoint: 000622
- to stream Main, to step Merge: 001813
- to stream Main, to step Curation: 001775
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functional balance between haemagglutinin and neuraminidase in influenza virus infections</title>
<author><name sortKey="Wagner, Ralf" sort="Wagner, Ralf" uniqKey="Wagner R" first="Ralf" last="Wagner">Ralf Wagner</name>
</author>
<author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
</author>
<author><name sortKey="Klenk, Hans Ieter" sort="Klenk, Hans Ieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:CA5DF7215C4873D815400E284DEA05BBFFDA15DB</idno>
<date when="2002" year="2002">2002</date>
<idno type="doi">10.1002/rmv.352</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-9T85ZXDT-G/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000482</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000482</idno>
<idno type="wicri:Area/Istex/Curation">000482</idno>
<idno type="wicri:Area/Istex/Checkpoint">000622</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000622</idno>
<idno type="wicri:doubleKey">1052-9276:2002:Wagner R:functional:balance:between</idno>
<idno type="wicri:Area/Main/Merge">001813</idno>
<idno type="wicri:Area/Main/Curation">001775</idno>
<idno type="wicri:Area/Main/Exploration">001775</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Functional balance between haemagglutinin and neuraminidase in influenza virus infections</title>
<author><name sortKey="Wagner, Ralf" sort="Wagner, Ralf" uniqKey="Wagner R" first="Ralf" last="Wagner">Ralf Wagner</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Virologie, Philipps‐Universität, 35011 Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Virologie, Philipps‐Universität, 35011 Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Russie</country>
<wicri:regionArea>M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, 142782 Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klenk, Hans Ieter" sort="Klenk, Hans Ieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Virologie, Philipps‐Universität, 35011 Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Correspondence address: Institut für Virologie, Philipps‐Universität Marburg, Postfach 2360, 35011Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Reviews in Medical Virology</title>
<title level="j" type="alt">REVIEWS IN MEDICAL VIROLOGY</title>
<idno type="ISSN">1052-9276</idno>
<idno type="eISSN">1099-1654</idno>
<imprint><biblScope unit="vol">12</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="159">159</biblScope>
<biblScope unit="page" to="166">166</biblScope>
<biblScope unit="page-count">8</biblScope>
<publisher>John Wiley & Sons, Ltd.</publisher>
<pubPlace>Chichester, UK</pubPlace>
<date type="published" when="2002-05">2002-05</date>
</imprint>
<idno type="ISSN">1052-9276</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1052-9276</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Amino</term>
<term>Arch virol</term>
<term>Avian</term>
<term>Cell culture</term>
<term>Cellular receptors</term>
<term>Copyright</term>
<term>Embryonated chicken eggs</term>
<term>Functional balance</term>
<term>Glycoprotein</term>
<term>Haemagglutinin</term>
<term>Hemagglutinin</term>
<term>Host cells</term>
<term>Human viruses</term>
<term>Inhibitor</term>
<term>John wiley sons</term>
<term>Mdck cells</term>
<term>Membrane fusion</term>
<term>Molecular species</term>
<term>Mutant</term>
<term>Mutation</term>
<term>Neuraminidase</term>
<term>Neuraminidase activity</term>
<term>Neuraminidase inhibitors</term>
<term>Parent virus</term>
<term>Progeny</term>
<term>Progeny virions</term>
<term>Reassortants</term>
<term>Receptor</term>
<term>Receptor binding</term>
<term>Receptor binding site</term>
<term>Recombinant viruses</term>
<term>Replication</term>
<term>Sialic</term>
<term>Sialic acid</term>
<term>Sialic acid receptors</term>
<term>Sialic acids</term>
<term>Surface glycoproteins</term>
<term>Viral</term>
<term>Virol</term>
<term>Virology</term>
<term>Virus</term>
<term>Virus neuraminidase</term>
<term>Virus reassortants</term>
<term>Virus release</term>
<term>Virus replication</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza A and B viruses carry two surface glycoproteins, the haemagglutinin (HA) and the neuraminidase (NA). Both proteins have been found to recognise the same host cell molecule, sialic acid. HA binds to sialic acid‐containing receptors on target cells to initiate virus infection, whereas NA cleaves sialic acids from cellular receptors and extracellular inhibitors to facilitate progeny virus release and to promote the spread of the infection to neighbouring cells. Numerous studies performed recently have revealed that an optimal interplay between these receptor‐binding and receptor‐destroying activities of the surface glycoproteins is required for efficient virus replication. An existing balance between the antagonistic HA and NA functions of individual viruses can be disturbed by various events, such as reassortment, virus transmission to a new host, or therapeutic inhibition of neuraminidase. The resulting decrease in the viral replicative fitness is usually overcome by restoration of the functional balance due to compensatory mutations in HA, NA or both proteins. Copyright © 2002 John Wiley & Sons, Ltd.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Russie</li>
</country>
<region><li>District de Giessen</li>
<li>District fédéral central</li>
<li>Hesse (Land)</li>
</region>
<settlement><li>Marbourg</li>
<li>Moscou</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Wagner, Ralf" sort="Wagner, Ralf" uniqKey="Wagner R" first="Ralf" last="Wagner">Ralf Wagner</name>
</region>
<name sortKey="Klenk, Hans Ieter" sort="Klenk, Hans Ieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<name sortKey="Klenk, Hans Ieter" sort="Klenk, Hans Ieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<name sortKey="Klenk, Hans Ieter" sort="Klenk, Hans Ieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
</country>
<country name="Russie"><region name="District fédéral central"><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001775 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001775 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:CA5DF7215C4873D815400E284DEA05BBFFDA15DB |texte= Functional balance between haemagglutinin and neuraminidase in influenza virus infections }}
This area was generated with Dilib version V0.6.33. |